Cannabis Use and the Endocannabinoid System in Bipolar Disorder

PI: William Perry, Ph.D. & Jared Young, Ph.D

STUDY LOCATION: University of California, San Diego

PROJECT TITLE: Cannabis Use and the Endocannabinoid System in Bipolar Disorder

PROJECT TYPE: Clinical Study

STATUS: Active

ABSTRACT:

This study will look at the impact of chronic cannabis use as well as the effects of acute administration of the principal constituents of cannabis on cognition and brain levels of endogenous cannabinoids and the neurotransmitter dopamine.

Cannabis use is highly prevalent in people with Bipolar Disorder (BD) and likely results in significant cognitive and behavioral disturbance in a population already vulnerable to cognitive deficits. Parallel studies in rodent models of BD will enhance the understanding of the neurobiology of cannabis use from acute, chronic, and withdrawal perspectives, and may ultimately lead to novel treatment targets.