Effects of cannabidiol and tetrahydrocannabinol on the microbiome, endocannabinoids and neuroinflammation in HIV  

PI: Ron Ellis, MD, PhD

This study will examine the microbiome and endocannabinoid system in people with HIV and how they relate to neuroinflamation and the blood-brain-barrier.

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Efficacy of inhaled cannabis versus placebo for the acute treatment of migraine

PI: Nathaniel Schuster, MD

This is a clinical study to determine the effect of THC and CBD on acute migraine.

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The Effects of THC on Glucose Metabolism and Endothelial Function in Subjects with Type 2 Diabetes

PI: Jeremy Pettus, MD

This study will seek to determine the effects of THC use on glucose metabolism

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The role of cannabidiol in anandamide-related improvement in alexithymia and health outcomes

PI: Erin Morgan, PhD

This study will examine whether CBD will reduce alexithymia and inflammation in people with HIV

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Cannabis, inflammation, and the brain in persons with HIV

PI: Jennifer Iudicello, PhD

This study will examine the effects of chronic cannabis use and the role of the endocannabinoid system on persistent inflammation in people with HIV.

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Effects of CBD on blood pressure and substrate metabolism during metabolic syndrome

PI: Rudy Ortiz, PhD

This is a pre-clinical study regarding the effects of CBD on blood pressure and factors related to metabolic syndrome

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The Effects of Cannabidiol (CBD) on Symptoms of Severe Autism

PI: Doris Trauner, MD

This clinical trial is examining if and how cannabidiol (CBD), a chemical found in the cannabis plant, provides therapeutic benefit to children with severe autism spectrum disorder (ASD). The trial is funded by a grant from the Ray and Tye Noorda Foundation in partnership with and based on recommendations from the Wholistic Research and Education Foundation.

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Cannabidiol for Sedative/Hypnotic-sparing Management of Insomnia in Adults

PI: Mariana Cherner, PhD

It is estimated that up to a third US adults suffer from sleep problems, which are in turn associated with sub-optimal, and sometimes compromised, daily functioning.  Sedative and hypnotic medications constitute the main pharmacologic treatment for insomnia, but they are habit-forming and associated with adverse next-day “hangover” effects, including impaired driving and risk of falls.

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The Role of Cannabidiol (CBD) in Regulating Meal Time Anxiety in Anorexia Nervosa

PI: Guido Frank, MD

Because there are no proven treatments that normalize core symptoms in adult anorexia nervosa (AN), a disorder with high chronicity and mortality, many individuals seek out alternative approaches to care.  Recent evidence has suggested that exaggerated anxiety and diminished reward or motivation to eat play a key role in causing AN symptoms and poor outcome. 

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Cannabis Use and the Endocannabinoid System in Bipolar Disorder

PI: William Perry, Ph.D. & Jared Young, Ph.D

This study will look at the impact of chronic cannabis use as well as the effects of acute administration of the principal constituents of cannabis on cognition and brain levels of endogenous cannabinoids and the neurotransmitter dopamine.

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Engaging the endocannabinoid system with cannabidiol to reduce anxiety reactivity

PI: Charles Taylor, PhD

This is a clinical study to determine the effect of CBD on anxiety disorders.

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Impact of Cannabis Exposure on Gut Barrier Function in Health and Disease

PI: Nicholas DiPatrizio, PhD

This study will examine the impact of cannabis exposure on gut barrier function in metabolic disease and experimental colitis

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Therapeutic Efficacy of Cannabis and Cannabinoids in Prescription Opioid Abuse and Addiction

PI: Michael Taffe, PhD

This study will examine the effects of cannabis and cannabinoids on the behavioral and molecular outcomes of motivational and stress-mediated changes associated with prescription oxycodone addiction and dependence.

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Cannabis effects on antiretroviral therapy pharmacokinetics and neurotoxicity

PI: Scott Letendre, MD

This is a clinical study looking at the intersection of cannabis, HIV, and the Central Nervous System.

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Translational studies of cannabis administration, cognition, and the endocannabinoid system in HIV

PI: Arpi Minassian, PhD

This study will utilize a cross-species approach to delineate the effects EC system activation has on HIV-relevant cognitive and motivational domains.

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Analgesic, appetite-stimulating, and subjective effects of cannabigerol administered alone and in combination with delta-9-tetrahydrocannabinol

PI: Ziva Cooper, PhD

This clinical trial will examine the effects of combining THC and cannabigerol on pain and other outcomes.

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Effects of Cannabidiol (CBD) versus Placebo as an Adjunct to Treatment in Early Psychosis

PI: Kristin Cadenhead, MD

This clinical trial will explore the effectiveness of cannabidiol (CBD), in reducing symptoms and improving cognition in early psychosis. Additionally, this trial will examine the effect of CBD on the biological response to stress, and the effect of CBD on eating behavior induced by antipsychotic medication.

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Cannabidiol as a Strategy to Treat Alcohol Dependence

PI: Giordano de Guglielmo, PharmD, PhD

The development of novel and more effective medications for alcohol use disorder (AUD) is a pressing medical need. Preclinical studies showed that chronic cannabidiol (CBD) treatment decreased alcohol drinking and prevented the reinstatement of alcohol seeking that was induced by environmental cues and stress.

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Therapeutic Response of Cannabidiol in Rheumatoid Arthritis

PI: Veena Ranganath, MD

The overall goal of this proof-of-principle proposal is to examine the efficacy and safety of CBD treatment as adjunctive to the medical management of Rheumatoid Arthritis (RA) patients with moderate to severe disease activity.

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Effect of Cannabis and Endocannabinoids on HIV Neuropathic Pain

PI: Brook Henry, Ph.D. & Ron Ellis, M.D., Ph.D.

This study will address these three fundamental gaps in our knowledge by: 1) examining the acute effects of various CBD/THC products on HIV-NP, 2) utilizing a mHealth text messaging protocol (Individual Monitoring of Pain and Cannabis Taken or IMPACT) to monitor daily real-world cannabis use and changes in pain; 3) studying the relationship between cannabinoids, EC biomarkers, and chronic neuropathic pain.

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