The Effects of Cannabidiol (CBD) on Symptoms of Severe Autism
PI: Doris Trauner, MD
This clinical trial will examine if and how cannabidiol (CBD), a chemical found in the cannabis plant, provides therapeutic benefit to children with severe autism spectrum disorder (ASD). The trial, funded by a grant from the Ray and Tye Noorda Foundation in partnership with and based on recommendations from the Wholistic Research and Education Foundation.
Cannabidiol for Sedative/Hypnotic-sparing Management of Insomnia in Adults
PI: Mariana Cherner, PhD
It is estimated that up to a third US adults suffer from sleep problems, which are in turn associated with sub-optimal, and sometimes compromised, daily functioning. Sedative and hypnotic medications constitute the main pharmacologic treatment for insomnia, but they are habit-forming and associated with adverse next-day “hangover” effects, including impaired driving and risk of falls.
The Role of Cannabidiol (CBD) in Regulating Meal Time Anxiety in Anorexia Nervosa
PI: Emily Gray, MD
Because there are no proven treatments that normalize core symptoms in adult anorexia nervosa (AN), a disorder with high chronicity and mortality, many individuals seek out alternative approaches to care. Recent evidence has suggested that exaggerated anxiety and diminished reward or motivation to eat play a key role in causing AN symptoms and poor outcome.
Cannabis Use and the Endocannabinoid System in Bipolar Disorder
PI: William Perry, Ph.D. & Jared Young, Ph.D
This study will look at the impact of chronic cannabis use as well as the effects of acute administration of the principal constituents of cannabis on cognition and brain levels of endogenous cannabinoids and the neurotransmitter dopamine.
Study to Examine Possible Effects of Cannabis Compound for Common Movement Disorder
PI: Fatta Nahab, MD
Scheduled for early 2019, the phase I/II trial will assess efficacy and tolerability of an oral cannabis formulation comprised of cannabidiol (CBD) and low-dose tetrahydrocannabinol (THC). This will be the first time this combination has been studied for treatment of ET.
Effect of Cannabis and Endocannabinoids on HIV Neuropathic Pain
PI: Brook Henry, Ph.D. & Ron Ellis, M.D., Ph.D.
This study will address these three fundamental gaps in our knowledge by: 1) examining the acute effects of various CBD/THC products on HIV-NP, 2) utilizing a mHealth text messaging protocol (Individual Monitoring of Pain and Cannabis Taken or IMPACT) to monitor daily real-world cannabis use and changes in pain; 3) studying the relationship between cannabinoids, EC biomarkers, and chronic neuropathic pain.