Scientific Publications

Piomelli D, Solomon R, Abrams D, Balla A, Grant I, Marcotte T, Yoder J. (2019). Regulatory barriers to research on cannabis and cannabinoids: a proposed path forward. Cannabis and Cannabinoid Research. 4:1, 21–32, DOI: 10.1089/can.2019.0010.

Sobolesky PM, Smith BE, Hubbard JA, Stone J, Marcotte TD, Grelotti DJ, Grant I, Fitzgerald RL. (2019). Validation of a liquid chromatography-tandem mass spectrometry method for analyzing cannabinoids in oral fluid. Clinica Chimica Acta; International Journal of Clinical Chemistry. 2019 Apr;491:30-38. doi: 10.1016/j.cca.2019.01.002. Epub 2019 Jan 4.

Shi Y, Liang D, Bao Y, An R, Wallace MS, Grant I. (2019). Recreational marijuana legalization and prescription opioids received by Medicaid enrollees. Drug and Alcohol Dependence. 2019 Jan 1;194:13-19. doi: 10.1016/j.drugalcdep.2018.09.016. Epub 2018 Oct 25.

Tyree GA, Sarkar R, Bellows BK, Ellis RJ, Atkinson JH, Marcotte TD, Wallace MS, Grant I, Shi Y, Murphy JD, Grelotti DJ. (2019). A Cost-Effectiveness Model for Adjunctive Smoked Cannabis in the Treatment of Chronic Neuropathic Pain. Cannabis and Cannabinoid Research. 2019 Jan 24;4(1):62-72. doi: 10.1089/can.2018.0027. [Epub ahead of print]

Liang D, Bao Y, Wallace M, Grant I, Shi Y. (2018). Medical cannabis legalization and opioid prescriptions: evidence on US Medicaid enrollees during 1993-2014. Addiction. 2018 Jul 10;113(11):2060-2070. doi: 10.1111/add.14382. [Epub ahead of print]

Lochte BC, Beletsky A, Samuel NK, Grant I. (2017). The Use of Cannabis for Headache Disorders. Cannabis and Cannabinoid Research. April 2017, 2(1): 61-71. doi: 10.1089/can.2016.0033.

Wilsey B, Marcotte TD, Deutsch R, Zhao H, Prasad H, Phan A. (2016). An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain from Spinal Cord Injury and Disease. J Pain. 2016 Jun 7. pii: S1526-5900(16)30072-4. doi: 10.1016/j.jpain.2016.05.010.

Andreae MH, Carter GM, Shaparin N, Suslov K, Ellis RJ, Ware MA, Abrams DI, Prasad H, Wilsey B, Indyk D, Johnson M, Sacks HS. (2015). Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data. J Pain. 2015 Dec;16(12):1221-32. doi: 10.1016/j.jpain.2015.07.009. Epub 2015 Sep 9.

Grant I. (2015). Medical Use of Cannabinoids. JAMA. 2015 Oct 27;314(16):1750-1. doi: 10.1001/jama.2015.11429.

Wallace MS, Marcotte TD, Umlauf A, Gouaux B, Atkinson JH. (2015). Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy. J Pain. 2015 Jul;16(7):616-27. doi: 10.1016/j.jpain.2015.03.008. Epub 2015 Apr 3.

Wilsey B, Marcotte T, Deutsch R, Gouaux B, Sakai S, Donaghe H. (2013). Low-Dose Vaporized Cannabis Significantly Improves Neuropathic Pain. J Pain. 2013 Feb;14(2):136-48. doi: 10.1016/j.jpain.2012.10.009. Epub 2012 Dec 11.

Grant I, Atkinson JH, Gouaux B. (2012). Research on medical marijuana. Am J Psychiatry, 169(10):1119-20. DOI: 10.1176/appi.ajp.2012.12060791.

Corey-Bloom J, Wolfson T, Gamst A, Jin S, Marcotte T, Bentley H, Gouaux B. (2012). Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial. CMAJ. 2012 Jul 10;184(10):1143-50. doi: 10.1503/cmaj.110837. Epub 2012 May 14.

Grant I, Atkinson JH, Gouaux B, Wilsey B. (2012). Medical Marijuana: Clearing Away the Smoke. The Open Neurology Journal. 2012 May 4, 6:18-25. DOI: 10.2174/1874205X01206010018.

Riggs PK, Vaida F, Rossi SR, Sorkin LS, Gouaux B, Grant I, Ellis RJ. (2011). A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men. Brain Research. 2012 Jan 11;1431:46-52. Epub 2011 Nov 7.

Center for Medicinal Cannabis Research: Report to the California Legislature (2010)

Ellis RJ, Toperoff W, Vaida F, van den Brande G, Gonzales J, Gouaux B, Bentley H, Atkinson JH. (2009). Smoked Medicinal Cannabis for Neuropathic Pain in HIV: A Randomized, Crossover Clinical Trial. Neuropsychopharmacology. 2009 Feb;34(3):672-80. doi: 10.1038/npp.2008.120. Epub 2008 Aug 6.

Corey-Bloom J, Wolfson T, Gamst A, Jin S, Marcotte T, Bentley H, Gouaux B. Short-Term Effects of Medicinal Cannabis on Spasticity in Multiple Sclerosis. Poster presented at the 60th Annual Meeting of the American Academy of Neurology (Chicago, IL). 2008.

Wilsey B, Marcotte T, Tsodikov A, Millman J, Bentley H, Gouaux B, Fishman S. (2008) A Randomized, Placebo-Controlled, Crossover Trial of Cannabis Cigarettes in Neuropathic Pain. J Pain. 2008 Jun;9(6):506-21. doi: 10.1016/j.jpain.2007.12.010. Epub 2008 Apr 10.

Wallace M, Schulteis G, Atkinson JH, Wolfson T, Lazzaretto D, Bentley H, Gouaux B, Abramson I (November 2007) Dose-dependent Effects of Smoked Cannabis on Capsaicin-induced Pain and Hyperalgesia in Healthy Volunteers. Anesthesiology. 2007 Nov;107(5):785-96.

Gonzalez R, Martin EM, Grant I, Neuropsychology and Substance Use, Taylor & Francis Group. (2007) Marijuana (Chapter 5, 139-170)

Abrams DI, Vizoso HP, hade SB, Jay C, Kelly ME, and Benowitz NL. (2007). Vaporization as a Smokeless Cannabis Delivery System: A Pilot Study. Clin Pharmacol Ther. 2007 Nov;82(5):572-8. Epub 2007 Apr 11.

Abrams DI, Jay CA, Shade SB, Vizoso H, Reda H, Press S, Kelly ME, Rowbotham MC, Petersen KL. Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo-controlled trial. Neurology. 2007 Feb 13;68(7):515-21.

Rossi S, Yaksh T, Bentley H, van den Brande G, Grant I, Ellis R. (2006). Characterization of interference with 6 commercial delta9-tetrahydrocannabinol immunoassays by efavirenz (glucuronide) in urine. Clin Chem. 2006 May;52(5):896-7.

Igor Grant and B. Rael Cahn, Cannabis and endocannabinoid modulators: Therapeutic promises and challenges. Clin Neurosci Res. 2005;5(2-4):185-199.

Abrams, D., Jay, C., Vizoso, H., Shade, S., Reda, H., Press, S., Kelley, M.E., Rowbotham, M., Petersen, K. Smoked Cannabis Therapy for HIV-Related Painful Peripheral Neuropathy: Results of a Randomized, Placebo-Controlled Clinical Trial. 2nd Annual Meeting of the International Association for Cannabis as Medicine. 2005.

Ilan, A., Gevins, A., Role, K., Vizoso, H., Abrams, D. The Cognitive Neurophysiological Effects of Medicinal Marijuana in HIV+ Patients with Peripheral Neuropathy. 2nd Annual Meeting of the International Association for Cannabis as Medicine. 2005.

Abrams, D., Vizoso, H., Shade, S., Jay, C., Kelley, M.E., Benowitz, N. Vaporization as a Smokeless Cannabis Delivery System: A Pilot Study. 2nd Annual Meeting of the International Association for Cannabis as Medicine. 2005.

Marcotte, T., Rosenthal, T., Corey-Bloom, J., Roberts, E., Lampinen, S., Allen, W. The Impact of Cognitive Deficits and Spasticity on Driving Simulator Performance in Multiple Sclerosis. Proceedings of the Third International Driving Symposium on Human Factors in Driver Assessment, Training, and Vehicle Design. 2005.

Lopez, C., Toperoff, W., van den Brande, G., Tapert, S., Atkinson, J.H., Drummond, S.P.A., Increased Sleep Disturbances in Patients with HIV-Related Neuropathy. 2005 Annual Meeting of the Associated Professional Sleep Societies.

Igor Grant, Foreword by Igor Grant, M.D., Director, Center for Medicinal Cannabis Research (CMCR). Neuropharmacology. 2005 Jun;48(8):1067.

Alexandros Makriyannis, Raphael Mechoulam and Daniele Piomelli, Therapeutic opportunities through modulation of the endocannabinoid system. Neuropharmacology. 2005 Jun;48(8):1068-71.

Cecilia J. Hillard and Abbas Jarrahian, Accumulation of anandamide: Evidence for cellular diversity. Neuropharmacology. 2005 Jun;48(8):1072-78.

Natsuo Ueda, Kazuhito Tsuboi and Didier M. Lambert, A second N-acylethanolamine hydrolase in mammalian tissues. Neuropharmacology. 2005 Jun;48(8):1079-85.

Shou-Yuan Zhuang, Daniel Bridges, Elena Grigorenko, Stephen McCloud, Andrew Boon, Robert E. Hampson and Sam A. Deadwyler, Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores. Neuropharmacology. 2005 Jun;48(8):1086-96.

Liana Fattore, Sabrina Spano, Gregorio Cossu, Serena Deiana, Paola Fadda and Walter Fratta, Cannabinoid CB1 antagonist SR 141716A attenuates reinstatement of heroin self-administration in heroin-abstinent rats. Neuropharmacology. 2005 Jun;48(8):1097-1104.

Carl R. Lupica and Arthur C. Riegel, Endocannabinoid release from midbrain dopamine neurons: a potential substrate for cannabinoid receptor antagonist treatment of addiction. Neuropharmacology. 2005 Jun;48(8):1105-16.

Ester Fride, Datta Ponde, Aviva Breuer and Lumir Hanus, Peripheral, but not central effects of cannabidiol derivatives: Mediation by CB1 and unidentified receptors. Neuropharmacology. 2005 Jun;48(8):1117-29.

Pàl Pacher, Sàndor Bàtkai and George Kunos, Blood pressure regulation by endocannabinoids and their receptors. Neuropharmacology. 2005 Jun;48(8):1130-38.

Roger G. Pertwee, Adèle Thomas, Lesley A. Stevenson, Yehoshua Maor and Raphael Mechoulam, Evidence that (-)-7-hydroxy-4'-dimethylheptyl-cannabidiol activates a non-CB1, non-CB2, non-TRPV1 target in the mouse vas deferens. Neuropharmacology. 2005 Jun;48(8):1139-46.

Jin Fu, Fariba Oveisi, Silvana Gaetani, Edward Lin and Daniele Piomelli, Oleoylethanolamide, an endogenous PPAR-[alpha] agonist, lowers body weight and hyperlipidemia in obese rats. Neuropharmacology. 2005 Jun;48(8):1147-53.

Nissar A. Darmani, Angelo A. Izzo, Brian Degenhardt, Marta Valenti, Giuseppe Scaglione, Raffaele Capasso, Italo Sorrentini and Vincenzo Di Marzo, Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: Review of the available pre-clinical data, and first human studies. Neuropharmacology. 2005 Jun;48(8):1154-63.

Kahlid Salim, Udo Schneider, Sumner Burstein, Ludwig Hoy and Matthias Karst, Pain measurements and side effect profile of the novel cannabinoid ajulemic acid. Neuropharmacology. 2005 Jun;48(8):1164-71.

de Jong, B.C., Prentiss, D., McFarland, W., Machekano, R., and Israelski, D.M. (2005) Marijuana use and its association with adherence to antiretroviral therapy among HIV-infected persons with moderate to severe nausea. J Acquir Immune Defic Syndr. 2005 Jan 1;38(1):43-6.

Giuffrida A, Leweke FM, Gerth CW, Schreiber D, Koethe D, Faulhaber J, Klosterkotter J, Piomelli D. Cerebrospinal Anandamide Levels are Elevated in Acute Schizophrenia and are Inversely Correlated with Psychotic Symptoms. Neuropsychopharmacology. 2004 Nov;29(11):2108-14.

Schrier, R., Soto, P., Hamlat, C., Durand, D., Ceci, K., Ellis, R. (2004, 3). Effects of in Vitro Cannabinoids on T-cell Responses of HIV Infected Patients. Poster presented at the 10th Society on Neuroimmune Pharmacology Conference (Santa Fe, NM).

Jay, C., Shade, S., Vizoso, H., Reda, H., Petersen, K., Rowbotham, M., Abrams, D. The Effect of Smoked Marijuana on Chronic Neuropathic and Experimentally-Induced Pain in HIV Neuropathy: Results of an Open-Label Pilot Study. Proceedings 11th Conference on Retroviruses and Opportunistic Infections, abstract 496, p.243, 2004.

A.M. Papanastassiou, H.L. Fields, I.D. Meng. Local application of the cannabinoid receptor agonist, WIN 55,212-2, to spinal trigeminal nucleus caudalis differentially affects nociceptive and non-nociceptive neurons. Pain. 2004 Feb;107(3):267-75.

Diane Prentiss, MA, MPH, Rachel Power, PhD, Gladys Balmas MD, MPH, Gloria Tzuang, MPH, and Dennis M. Israelski, MD. Patterns of Marijuana Use Among Patients With HIV/AIDS Followed in a Public Health Care Setting. J Acquir Immune Defic Syndr. 2004 Jan 1;35(1):38-45.

Abrams, D.I., Jay, C., Petersen, K., Shade, S., Vizoso, H., Reda, H., Benowitz, N., Rowbotham, M. The Effects of Smoked Cannabis in Painful Peripheral Neuropathy and Cancer Pain Refractory to Opioids. Proceedings of the International Association of Cannabis as Medicine, Cologne, 2003, p.28.

Grant, I., Gonzalez, R., Carey, C., Natarajan, L., and Wolfson, T. (2003). Non-acute (residual) neurocognitive effects of cannabis use: A meta-analysis study. J Int Neuropsychol Soc. 2003 Jul;9(5):679-89.

Gonzalez R., Carey, C., and Grant, I. Nonacute (Residual) Neuropsychological Effects of Cannabis Use: A Qualitative Analysis and Systemic Review. J Clin Pharmacol. 2002 Nov;42(11 Suppl):48S-57S.

Igor Grant, MD

Marijuana as Medicine: Can We See Past the Smoke?
North American Cannabis Summit presentation January 2019 (PDF)

Igor Grant, MD

CMCR Symposium, June 2018

Daniele Piomelli, MD, PhD, PharmD

The health impact of cannabis
CMCR Symposium, June 2018

Ziva Cooper, PhD

Therapeutic potential of cannabis for pain alone and as an adjunct to opioids
CMCR Symposium, June 2018

Iain McGregor, PhD

Medicinal cannabis research down under: Introducing the Lambert Initiative for Cannabinoid Therapeutics
CMCR Symposium, June 2018

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