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Current Studies

Effect of Cannabis and Endocannabinoids on HIV Neuropathic Pain

PI: Brook Henry, Ph.D. & Ron Ellis, M.D., Ph.D.

This study will address these three fundamental gaps in our knowledge by: 1) examining the acute effects of various CBD/THC products on HIV-NP, 2) utilizing a mHealth text messaging protocol (Individual Monitoring of Pain and Cannabis Taken or IMPACT) to monitor daily real-world cannabis use and changes in pain; 3) studying the relationship between cannabinoids, EC biomarkers, and chronic neuropathic pain.

Effects of Cannabidiol (CBD) versus Placebo as an Adjunct to Treatment in Early Psychosis

PI: Kristin Cadenhead, MD

This clinical trial will explore the effectiveness of cannabidiol (CBD), in reducing symptoms and improving cognition in early psychosis. Additionally, this trial will examine the effect of CBD on the biological response to stress, and the effect of CBD on eating behavior induced by antipsychotic medication.

Effects of cannabidiol and tetrahydrocannabinol on the microbiome, endocannabinoids and neuroinflammation in HIV  

PI: Ron Ellis, MD, PhD

This study will examine the microbiome and endocannabinoid system in people with HIV and how they relate to neuroinflamation and the blood-brain-barrier.

Efficacy of inhaled cannabis versus placebo for the acute treatment of migraine

PI: Nathaniel Schuster, MD

This is a clinical study to determine the effect of THC and CBD on acute migraine.

Engaging the endocannabinoid system with cannabidiol to reduce anxiety reactivity

PI: Charles Taylor, PhD

This is a clinical study to determine the effect of CBD on anxiety disorders.

Impact of Cannabis Exposure on Gut Barrier Function in Health and Disease

PI: Nicholas DiPatrizio, PhD

This study will examine the impact of cannabis exposure on gut barrier function in metabolic disease and experimental colitis

The Effects of Cannabidiol (CBD) on Symptoms of Severe Autism

PI: Doris Trauner, MD

This clinical trial is examining if and how cannabidiol (CBD), a chemical found in the cannabis plant, provides therapeutic benefit to children with severe autism spectrum disorder (ASD). The trial is funded by a grant from the Ray and Tye Noorda Foundation in partnership with and based on recommendations from the Wholistic Research and Education Foundation.

The Effects of THC on Glucose Metabolism and Endothelial Function in Subjects with Type 2 Diabetes

PI: Jeremy Pettus, MD

This study will seek to determine the effects of THC use on glucose metabolism

The Role of Cannabidiol (CBD) in Regulating Meal Time Anxiety in Anorexia Nervosa

PI: Guido Frank, MD

Because there are no proven treatments that normalize core symptoms in adult anorexia nervosa (AN), a disorder with high chronicity and mortality, many individuals seek out alternative approaches to care.  Recent evidence has suggested that exaggerated anxiety and diminished reward or motivation to eat play a key role in causing AN symptoms and poor outcome. 

The role of cannabidiol in anandamide-related improvement in alexithymia and health outcomes

PI: Erin Morgan, PhD

This study will examine whether CBD will reduce alexithymia and inflammation in people with HIV

Therapeutic Efficacy of Cannabis and Cannabinoids in Prescription Opioid Abuse and Addiction

PI: Michael Taffe, PhD

This study will examine the effects of cannabis and cannabinoids on the behavioral and molecular outcomes of motivational and stress-mediated changes associated with prescription oxycodone addiction and dependence.

Therapeutic Response of Cannabidiol in Rheumatoid Arthritis

PI: Veena Ranganath, MD

The overall goal of this proof-of-principle proposal is to examine the efficacy and safety of CBD treatment as adjunctive to the medical management of Rheumatoid Arthritis (RA) patients with moderate to severe disease activity.

Translational studies of cannabis administration, cognition, and the endocannabinoid system in HIV

PI: Arpi Minassian, PhD

This study will utilize a cross-species approach to delineate the effects EC system activation has on HIV-relevant cognitive and motivational domains.