Effects of Cannabidiol (CBD) versus Placebo as an Adjunct to Antipsychotics in Early Psychosis (PI: Kristin Cadenhead, MD)

This clinical trial will explore the effectiveness of cannabidiol (CBD), in reducing symptoms and improving cognition in early psychosis. Additionally, this trial will examine the effect of CBD on the biological response to stress, and the effect of CBD on eating behavior induced by antipsychotic medication. This trial is funded by a Krupp Endowed Fund (KEF) grant.

Schizophrenia and related psychotic disorders are neurodevelopmental disorders that fully emerge during late adolescence or early adulthood and are a leading cause of morbidity, mortality and disability. Individuals in the early stages of psychosis (EP) respond to antipsychotic medication in terms of their positive psychotic symptoms (e.g. hallucinations, delusions, etc.), but the negative and neurocognitive symptoms (e.g. lack of emotional expression, memory/concentration deficits, etc.) are very difficult to treat, leading to long term difficulties in social, role and global functioning and lifelong disability. In addition, the metabolic abnormalities that often accompany psychotic illness lead to chronic medical issues.

The goals of this study are to determine if adding CBD to established antipsychotic treatment in an early psychosis population 1) reduces psychotic symptoms; 2) reduces cognitive deficits; 3) normalizes hormonal and neuroimmune responses to psychosocial stress; and 4) modulates appetite and eating behavior.

The clinical trial will consist of 78 adult patients who are diagnosed with first episode psychosis and stabilized on antipsychotic medication. Participants will be randomized to receive either an oral dose of CBD or a placebo to augment their medication for six weeks. Investigators will be blinded to which participants are randomized to receive the CBD or placebo until the participant has completed all study measures.

To stay informed about the study please contact Sandra Sanchez at 619.543.1851.

Igor Grant, MD

Introduction/Overview
CMCR Symposium, June 2018


Daniele Piomelli, MD, PhD, PharmD

The health impact of cannabis
CMCR Symposium, June 2018


Ziva Cooper, PhD

Therapeutic potential of cannabis for pain alone and as an adjunct to opioids
CMCR Symposium, June 2018


Iain McGregor, PhD

Medicinal cannabis research down under: Introducing the Lambert Initiative for Cannabinoid Therapeutics
CMCR Symposium, June 2018


Thomas Marcotte, PhD

Cannabis and public safety: The challenge of cannabis-impaired driving
CMCR Symposium, June 2018


Alan Budney, PhD

Medicinal cannabis / legalization and the development of cannabis use problems
CMCR Symposium, June 2018


Ryan Vandrey, PhD

What's in real-world cannabis?
CMCR Symposium, June 2018


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