Cannabis Use and the Endocannabinoid System in Bipolar Disorder

INVESTIGATORS: William Perry, Ph.D. & Jared Young, Ph.D.

STUDY LOCATION: University of California, San Diego

PROJECT TITLE: Cannabis Use and the Endocannabinoid System in Bipolar Disorder


PROJECT TYPE: Clinical Study



Cannabis use is highly prevalent in people with Bipolar Disorder (BD) and likely results in significant cognitive and behavioral disturbance in a population already vulnerable to cognitive deficits. This study will look at the impact of chronic cannabis use in BD as well as the effects of acute oral administration of the principal constituents of cannabis like THC and CBD on cognition and brain levels of endogenous cannabinoids and the neurotransmitter dopamine. Parallel studies in rodent models of BD will enhance the understanding of the neurobiology of cannabis use from acute, chronic, and withdrawal perspectives, and may ultimately lead to novel treatment targets.


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