Cannabis exposure is associated with a lower likelihood of neurocognitive impairment in people living with HIV
Findings suggest cannabis exposure is linked to a lower odds of neurocognitive impairment in the context of HIV. A possible mechanism of this result is the anti-inflammatory effect of cannabis, which may be particularly important for people living with HIV.
|Type: Published Manuscript|
|Title: Cannabis exposure is associated with a lower likelihood of neurocognitive impairment in people living with HIV|
|Authors: Watson CW, Paolillo EW, Morgan EE, Umlauf A, Sundermann EE, Ellis RJ, Letendre
S, Marcotte TD, Heaton RK, Grant I
|Publication: Journal of Acquired Immune Deficiency Syndromes|
|Volume: 83 Issue: 1 Pages: 56-64|
BACKGROUND: Aging and HIV have adverse effects on the central nervous system, including increased inflammation and neural injury and confer risk of neurocognitive impairment (NCI). Previous research suggests the nonacute neurocognitive effects of cannabis in the general population are adverse or null. However, in the context of aging and HIV, cannabis use may exert beneficial effects due to its anti-inflammatory properties. In the current study, we examined the independent and interactive effects of HIV and cannabis on NCI and the potential moderation of these effects by age.