Effect of Cannabis and Endocannabinoids on HIV Neuropathic Pain

INVESTIGATORS: Brook Henry, Ph.D. & Ron Ellis, M.D., Ph.D.

STUDY LOCATION: University of California, San Diego

PROJECT TITLE: Effect of Cannabis and Endocannabinoids on HIV Neuropathic Pain

PROJECT TYPE: Clinical Study

STATUS: ACTIVE

ABSTRACT:

HIV-associated neuropathic pain (HIV-NP) affects a significant proportion of people living with HIV (PLWH) and is one of the leading causes of disability in this population. Acute cannabis administration is reported to alleviate HIV-NP, but we have limited knowledge about the effects of cannabis constituents (THC and cannabidiol/CBD), the consequences of long-term cannabis use, and the impact of cannabis on endocannabinoid (EC) function in PLWH. Our objective is to address these three fundamental gaps in our knowledge by: 1) examining the acute effects of various CBD/THC products on HIV-NP, 2) utilizing a mHealth text messaging protocol (Individual Monitoring of Pain and Cannabis Taken or IMPACT) to monitor daily real-world cannabis use and changes in pain; 3) studying the relationship between cannabinoids, EC biomarkers, and chronic neuropathic pain.

 

Igor Grant, MD

Introduction/Overview
CMCR Symposium, June 2018


Daniele Piomelli, MD, PhD, PharmD

The health impact of cannabis
CMCR Symposium, June 2018


Ziva Cooper, PhD

Therapeutic potential of cannabis for pain alone and as an adjunct to opioids
CMCR Symposium, June 2018


Iain McGregor, PhD

Medicinal cannabis research down under: Introducing the Lambert Initiative for Cannabinoid Therapeutics
CMCR Symposium, June 2018


Thomas Marcotte, PhD

Cannabis and public safety: The challenge of cannabis-impaired driving
CMCR Symposium, June 2018


Alan Budney, PhD

Medicinal cannabis / legalization and the development of cannabis use problems
CMCR Symposium, June 2018


Ryan Vandrey, PhD

What's in real-world cannabis?
CMCR Symposium, June 2018


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