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Current studies examine the effects of cannabis and cannabinoids on a range of psychiatric, developmental and pain conditions, as well as the impact of use on public safety (e.g., driving). A list of current and past studies can be found here.

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In order to foster discourse and facilitate the dissemination of new findings, the CMCR sponsors symposia covering a range of topics, including scientific findings and policy issues. Information on the CMCR symposium series, including archives of previous meetings, can be found here.

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The CMCR aims to advance cannabis science through the funding of scientific research projects via the CMCR Grants program. This program provides funding for studies that enhance the understanding of the efficacy and adverse effects of cannabis and cannabinoids as pharmacological agents, and their potential public health impacts. Click here for additional information.

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PI: Brook Henry, Ph.D. & Ron Ellis, M.D., Ph.D.

STUDY LOCATION: University of California, San Diego

PROJECT TITLE: Effect of Cannabis and Endocannabinoids on HIV Neuropathic Pain

PROJECT TYPE: Clinical Study

STATUS: Active (Enrolling)

ABSTRACT:

HIV-associated neuropathic pain (HIV-NP) affects a significant proportion of people living with HIV (PLWH) and is one of the leading causes of disability in this population. Acute cannabis administration is reported to alleviate HIV-NP, but we have limited knowledge about the effects of cannabis constituents (THC and cannabidiol/CBD), the consequences of long-term cannabis use, and the impact of cannabis on endocannabinoid (EC) function in PLWH. Our objective is to address these three fundamental gaps in our knowledge by: 1) examining the acute effects of various CBD/THC products on HIV-NP, 2) utilizing a mHealth text messaging protocol (Individual Monitoring of Pain and Cannabis Taken or IMPACT) to monitor daily real-world cannabis use and changes in pain; 3) studying the relationship between cannabinoids, EC biomarkers, and chronic neuropathic pain.

This study will address these three fundamental gaps in our knowledge by: 1) examining the acute effects of various CBD/THC products on HIV-NP, 2) utilizing a mHealth text messaging protocol (Individual Monitoring of Pain and Cannabis Taken or IMPACT) to monitor daily real-world cannabis use and changes in pain; 3) studying the relationship between cannabinoids, EC biomarkers, and chronic neuropathic pain.