A Randomized, Controlled Trial of Cannabis in Healthy Volunteers Evaluating Simulated Driving, Field Performance Tests and Cannabinoid Levels

INVESTIGATORS: Thomas Marcotte, Ph.D.

STUDY LOCATION: University of California, San Diego

PROJECT TITLE: A Randomized, Controlled Trial of Cannabis in Healthy Volunteers Evaluating Simulated Driving, Field Performance Tests and Cannabinoid Levels

FUNDING SOURCE: State of California

PROJECT TYPE: Clinical Study

STATUS: ACTIVE

ABSTRACT:

This study was authorized by the California Legislature (Assembly Bill 266, the Medical Marijuana Regulation and Safety Act) to help with detection of driving under the influence of cannabis. Healthy volunteers will inhale smoked cannabis with either 0% (placebo), 6.7%, or 12.6% Δ9-THC at the beginning of the day, and then complete driving simulations, iPad-based performance assessments, and bodily fluid draws (e.g., blood, saliva, breath) before the cannabis smoking and hourly over the subsequent 7 hours after cannabis smoking. The purpose is to determine (1) the relationship of the dose of Δ9-THC on driving performance and (2) the duration of driving impairment in terms of hours from initial use, (3) if saliva or expired air can serve as a useful substitute for blood sampling of Δ9-THC in judicial hearings and (4) if testing using an iPad can serve as a useful adjunct to the standardized field sobriety test in identifying acute impairment from cannabis.

 

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San Diego schools look to take mystery and misinformation out of medical marijuana

Jared Aarons, ABC 10News San Diego, September 10, 2019

Starting this fall, the Pacific College of Oriental Medicine is offering the first-ever certificate program specializing in medical marijuana.

The three-semester class promises to teach health care professionals the basics of medical cannabis, so they can begin to use it in their practice.

"We thought it was important for health care professionals to have objective information about medical marijuana," says school President Jack Miller.

Miller says part of the program's purpose is to help dispel some of the myths surrounding medical marijuana.

Read the rest of the story here


CMCR announces $3M in new research grants to California investigators

The Center for Medicinal Cannabis Research (CMCR) at UC San Diego has been a leader in medical marijuana research since 2000. In the past CMCR has allocated funds to investigators in California to conduct some of the first proof of principle clinical trials of cannabis in neuropathic pain and multiple sclerosis.

With the recent allocation of new funding to CMCR as part of Proposition 64, the CMCR has launched a new wave of grant applications aimed at examining both the efficacy and safety of medicinal cannabinoids. CMCR issued a call for applications to investigators in California in April 2019, received 66 letters of intent from 19 California institutions, and invited 26 applications for primary and pilot studies. Based on external peer review, advice of the CMCR’s National Advisory Council, and rating of attentiveness to CMCR priorities, the Center has selected 5 studies for funding this year. The studies to be funded are listed in the table below.

Study title Principal Investigator
Full funding amount
Effects of Cannabidiol (CBD) versus Placebo as an Adjunct to Treatment in Early Psychosis: Understanding the Mechanism and Mediators of Action Kristin Cadenhead, MD (UC San Diego)  $825,000 
Therapeutic Response of Cannabidiol in Rheumatoid Arthritis Veena Ranganath, MD (UCLA)  $825,000
Cannabidiol for Sedative/Hypnotic-sparing Management of Insomnia in Adults Mariana Cherner, PhD (UC San Diego)  $825,000
Cannabidiol as a Strategy to Treat Alcohol Dependence Giordano de Guglielmo, PhD (UC San Diego)  $300,000
The Role of Cannabidiol (CBD) in Regulating Meal Time Anxiety in Anorexia Nervosa: Safety, Tolerability and Pharmacokinetics Emily Gray, MD (UC San Diego)  $300,000

CMCR anticipates issuing a new call for applications in 2020.

Congratulations to the new CMCR Investigators!

- Igor Grant, MD, Director


The CBD Expert Series: Q&A with a National Leader in Cannabis Research

Nick Musica, CBD Oil Review, August 21, 2019

Recently, Nick Musica of CBD Oil Review had the privilege of speaking with one of the most influential figures in cannabis research, Dr. Igor Grant. Dr. Grant is the Director of the Center for Medicinal Cannabis Research (CMCR) at the University of California, San Diego, as well as a Distinguished Professor in the Department of Psychiatry.

Current CMCR studies are examining the effects of cannabis, and cannabidiol (CBD) specifically, on conditions like autism, psychosis, bipolar disorder, and pain, to name a few.

There is, quite possibly, no one who understands the benefits and effects of CBD better than Dr. Grant. Meet the researcher behind the research.

Read the article here


More News

Click here to access the CMCR news archives.

Igor Grant, MD

Marijuana as Medicine: Can We See Past the Smoke?
North American Cannabis Summit presentation January 2019 (PDF)


Igor Grant, MD

Introduction/Overview
CMCR Symposium, June 2018


Daniele Piomelli, MD, PhD, PharmD

The health impact of cannabis
CMCR Symposium, June 2018


Ziva Cooper, PhD

Therapeutic potential of cannabis for pain alone and as an adjunct to opioids
CMCR Symposium, June 2018


Iain McGregor, PhD

Medicinal cannabis research down under: Introducing the Lambert Initiative for Cannabinoid Therapeutics
CMCR Symposium, June 2018


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