CMCR studies

Current studies examine the effects of cannabis and cannabinoids on a range of psychiatric, developmental and pain conditions, as well as the impact of use on public safety (e.g., driving). A list of current and past studies can be found here.

CMCR Symposium

In order to foster discourse and facilitate the dissemination of new findings, the CMCR sponsors symposia covering a range of topics, including scientific findings and policy issues. Information on the CMCR symposium series, including archives of previous meetings, can be found here.

CMCR Grants Program

The CMCR aims to advance cannabis science through the funding of scientific research projects via the CMCR Grants program. This program provides funding for studies that enhance the understanding of the efficacy and adverse effects of cannabis and cannabinoids as pharmacological agents, and their potential public health impacts. Click here for additional information.

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PI: Doris Trauner, MD

STUDY LOCATION: University of California, San Diego

PROJECT TITLE: The Effects of Cannabidiol (CBD) on Symptoms of Severe Autism

FUNDING SOURCE: Wholistic Research and Education Foundation

PROJECT TYPE: Clinical Study

STATUS: Enrollment Pending

ABSTRACT:

This clinical trial will examine if and how cannabidiol (CBD), a chemical found in the cannabis plant, provides therapeutic benefit to children with severe autism spectrum disorder (ASD). The trial, funded by a grant from the Ray and Tye Noorda Foundation in partnership with and based on recommendations from the Wholistic Research and Education Foundation.

ASD affects an estimated one in 68 children in the United States, primarily boys. CBD is a major chemical compound found in cannabis. It does not produce the “highness” caused by THC but interacts with the body’s endocannabinoid system; a network that regulates diverse physiological and cognitive processes.

The goals of the study are to determine 1) if CBD is safe and tolerable and whether it helps with the symptoms of ASD; 2) whether and how CBD alters neurotransmitters and/or improves brain connectivity; and 3) whether biomarkers of neuro-inflammation, also associated with ASD, are altered by CBD.

The clinical trial will consist of 30 children, ages eight to 12 years, with a confirmed diagnosis of moderate to severe autism. They must be free of other neurological conditions, such as epilepsy, and in general good health.

In the first phase of the study, half the children will receive an oral dose of CBD and half placebo. In the second phase, the groups will be switched and the half who originally received CBD will receive placebo, while the initial placebo group will receive CBD. Investigators will be blinded to which children are receiving which treatment until after all of the testing is completed at the end of the study.

For more information about the CMCR, click here.

The study will not begin until the end of the year. Click here to sign up to receive information when the study is getting closer to beginning.