The Effects of Cannabidiol (CBD) on Symptoms of Severe Autism

INVESTIGATORS: Doris Trauner, MD

STUDY LOCATION: University of California, San Diego

PROJECT TITLE: The Effects of Cannabidiol (CBD) on Symptoms of Severe Autism

FUNDING SOURCE: Wholistic Research and Education Foundation

PROJECT TYPE: Clinical Study

STATUS: PENDING

ABSTRACT:

This clinical trial will examine if and how cannabidiol (CBD), a chemical found in the cannabis plant, provides therapeutic benefit to children with severe autism spectrum disorder (ASD). The trial is funded by a grant from the Ray and Tye Noorda Foundation in partnership with and based on recommendations from the Wholistic Research and Education Foundation.

ASD affects an estimated one in 68 children in the United States, primarily boys. CBD is a major chemical compound found in cannabis. It does not produce the “highness” caused by THC but interacts with the body’s endocannabinoid system; a network that regulates diverse physiological and cognitive processes.

The goals of the study are to determine 1) if CBD is safe and tolerable and whether it helps with the symptoms of ASD; 2) whether and how CBD alters neurotransmitters and/or improves brain connectivity; and 3) whether biomarkers of neuro-inflammation, also associated with ASD, are altered by CBD.

The clinical trial will consist of 30 children, ages eight to 12 years, with a confirmed diagnosis of moderate to severe autism. They must be free of other neurological conditions, such as epilepsy, and in general good health.

In the first phase of the study, half the children will receive an oral dose of CBD and half placebo. In the second phase, the groups will be switched and the half who originally received CBD will receive placebo, while the initial placebo group will receive CBD. Investigators will be blinded to which children are receiving which treatment until after all of the testing is completed at the end of the study.

For more information about the CMCR, click here.

We anticipate that this study will begin enrollment within the next few months. Click here to sign up to receive information when the study is getting closer to beginning.

San Diego schools look to take mystery and misinformation out of medical marijuana

Jared Aarons, ABC 10News San Diego, September 10, 2019

Starting this fall, the Pacific College of Oriental Medicine is offering the first-ever certificate program specializing in medical marijuana.

The three-semester class promises to teach health care professionals the basics of medical cannabis, so they can begin to use it in their practice.

"We thought it was important for health care professionals to have objective information about medical marijuana," says school President Jack Miller.

Miller says part of the program's purpose is to help dispel some of the myths surrounding medical marijuana.

Read the rest of the story here


CMCR announces $3M in new research grants to California investigators

The Center for Medicinal Cannabis Research (CMCR) at UC San Diego has been a leader in medical marijuana research since 2000. In the past CMCR has allocated funds to investigators in California to conduct some of the first proof of principle clinical trials of cannabis in neuropathic pain and multiple sclerosis.

With the recent allocation of new funding to CMCR as part of Proposition 64, the CMCR has launched a new wave of grant applications aimed at examining both the efficacy and safety of medicinal cannabinoids. CMCR issued a call for applications to investigators in California in April 2019, received 66 letters of intent from 19 California institutions, and invited 26 applications for primary and pilot studies. Based on external peer review, advice of the CMCR’s National Advisory Council, and rating of attentiveness to CMCR priorities, the Center has selected 5 studies for funding this year. The studies to be funded are listed in the table below.

Study title Principal Investigator
Full funding amount
Effects of Cannabidiol (CBD) versus Placebo as an Adjunct to Treatment in Early Psychosis: Understanding the Mechanism and Mediators of Action Kristin Cadenhead, MD (UC San Diego)  $825,000 
Therapeutic Response of Cannabidiol in Rheumatoid Arthritis Veena Ranganath, MD (UCLA)  $825,000
Cannabidiol for Sedative/Hypnotic-sparing Management of Insomnia in Adults Mariana Cherner, PhD (UC San Diego)  $825,000
Cannabidiol as a Strategy to Treat Alcohol Dependence Giordano de Guglielmo, PhD (UC San Diego)  $300,000
The Role of Cannabidiol (CBD) in Regulating Meal Time Anxiety in Anorexia Nervosa: Safety, Tolerability and Pharmacokinetics Emily Gray, MD (UC San Diego)  $300,000

CMCR anticipates issuing a new call for applications in 2020.

Congratulations to the new CMCR Investigators!

- Igor Grant, MD, Director


The CBD Expert Series: Q&A with a National Leader in Cannabis Research

Nick Musica, CBD Oil Review, August 21, 2019

Recently, Nick Musica of CBD Oil Review had the privilege of speaking with one of the most influential figures in cannabis research, Dr. Igor Grant. Dr. Grant is the Director of the Center for Medicinal Cannabis Research (CMCR) at the University of California, San Diego, as well as a Distinguished Professor in the Department of Psychiatry.

Current CMCR studies are examining the effects of cannabis, and cannabidiol (CBD) specifically, on conditions like autism, psychosis, bipolar disorder, and pain, to name a few.

There is, quite possibly, no one who understands the benefits and effects of CBD better than Dr. Grant. Meet the researcher behind the research.

Read the article here


More News

Click here to access the CMCR news archives.

Igor Grant, MD

Marijuana as Medicine: Can We See Past the Smoke?
North American Cannabis Summit presentation January 2019 (PDF)


Igor Grant, MD

Introduction/Overview
CMCR Symposium, June 2018


Daniele Piomelli, MD, PhD, PharmD

The health impact of cannabis
CMCR Symposium, June 2018


Ziva Cooper, PhD

Therapeutic potential of cannabis for pain alone and as an adjunct to opioids
CMCR Symposium, June 2018


Iain McGregor, PhD

Medicinal cannabis research down under: Introducing the Lambert Initiative for Cannabinoid Therapeutics
CMCR Symposium, June 2018


Copyright © 2019 CENTER FOR MEDICINAL CANNABIS RESEARCH. | University of California, San Diego
cmcr@ucsd.edu | HNRP |