Exploring the Entourage:
The Therapeutic Potential of Minor Cannabinoids, Terpenes, and Flavonoids

The Center for Medicinal Cannabis Research (CMCR) hosted a virtual, two-day symposium on October 12-13, 2023 highlighting the state of science in medicinal cannabis research. Whereas the majority of current research focuses on delta-9-THC and cannabidiol, the 2023 CMCR Symposium highlighted emerging clinical and translational research on the "other" constituents of cannabis (minor cannabinoids, terpenes, and flavonoids) and the entourage effect.

Day 1: Thursday, October 12, 2023

8:00-8:05 Welcome from the CMCR Director, Igor Grant, MD

2023 CMCR Symposium Awards

8:05-8:40 Marilyn Huestis, AB, MS, PhD - 2023 CMCR Pioneer in Medicinal Cannabis Research Award

Keynote Address - Thirty years of Human Cannabinoid Administration Studies Contributing to the Development of Medical Cannabinoids - LINK to VIDEO

This award honors leaders in cannabis and cannabinoid research conducting basic and translational research of cannabinoids, other constituents of cannabis, and the endocannabinoid system. The recipient’s work has led to significant advancements in our understanding of the mechanism and physiological effects of cannabinoids and related compounds.

8:40-9:15 Margaret Haney, PhD - 2023 CMCR Award for Advancing Cannabis and Cannabinoids as Therapeutics

Keynote Address - Cannabis Misuse and Therapeutic Potential: Placebo-controlled Laboratory Studies - LINK to VIDEO

This award honors those whose work has led to significant changes in our knowledge of or an expansion to the therapeutic use of cannabis and cannabinoid-based medicines. Recipients come from a diverse array of backgrounds, including drug development, medicine, public policy, and advocacy.

9:15-9:20 5-minute break

9:20-9:55 Moderated panel discussion and Q&A with 2023 CMCR Symposium Award Recipients - LINK to VIDEO

Videos of congratulations from 2022 Award Recipients - LINK to VIDEO from Dr. Daniele Piomelli & LINK to VIDEO from Dr. Donald Abrams

9:55-10:00 5-minute break

CMCR Special Lectures

10:00-10:20 Doris Trauner, MD - A Randomized Clinical Trial of Cannabidiol for Behavioral Problems in Boys with Severe Autism - LINK to VIDEO

10:20-10:30 Q&A moderated by JH Atkinson, MD

10:30-10:50 Marcel Bonn-Miller, PhD - A Double-Blind Randomized, Placebo-Controlled Study of the Safety and Effects of CBN With and Without CBD on Sleep Quality - LINK to VIDEO

10:50-10:55 Q&A discussion moderated by JH Atkinson, MD

10:55-11:00 5-minute break

Panel 1: Update on Federal activities affecting cannabis research

11:00-11:55 Panel discussion and Q&A moderated by Steve Gust, PhD, Advisor to CMCR

Panelists:

David Shurtleff, PhD, Deputy Director, National Center for Complementary and Integrative Health

Cassandra Taylor, PhD, Botanical Products, Center for Drug Evaluation and Research, US Food and Drug Administration

Richard (Rik) Kline, PhD, Chief, Chemistry and Pharmaceutics Branch, NIDA

11:55-12:00 Introduction to the poster session

12:00-1:00 Poster Session - LINK to VIDEOS

Day 2: Friday, October 13, 2023

State of the Science Lecture Series

The Entourage: Minor Cannabinoids, Terpenes, and Flavonoids

8:00-8:05 Welcome

8:05-8:20 Ziva Cooper, PhD - Assessing the Analgesic and Subjective Effects of Inhaled Beta-Caryophyllene Alone and with Delta-9 THC in healthy volunteers - LINK to VIDEO

8:20-8:35 Ryan Vandrey, PhD - Behavioral Pharmacology of D-Limonene and THC - LINK to VIDEO

8:35-8:50 Sara Jane Ward, PhD - Anti-allodynic effects of Beta-caryophyllene in rodent models of neuropathic pain - LINK to VIDEO

8:55-9:00 5-minute break

9:00-9:15 Jonathan C. Arnold, PhD - Anti-seizure and Entourage Effects of Plant Cannabinoids in Preclinical Models - LINK to VIDEO

9:15-9:30 John Streicher, PhD - Terpenes from Cannabis Sativa are Cannabimimetic and Selectively Enhance Cannabinoid Activity - LINK to VIDEO

9:30-10:00 Q&A moderated by Ziva Cooper, PhD and Patrick Still, PhD

10:00-10:05 5-minute break

Panel 2: Use of minor cannabinoids, terpenes, and flavonoids in the community

10:05-10:55 Panel discussion and Q&A moderated by Igor Grant, MD

Panelists:

Sherry Yafai, MD, Providence St. John's Medical Center

Bonni Goldstein, MD, Medical Director, CannaCenters

Michelle Sexton, ND, UC San Diego

Dale Gieringer, PhD, California NORML

10:55-11:00 5-minute break

11:00-11:20 Linda Hill, MD, MPH - The State of Cannabis: A Survey of 5,000 Californians - LINK to VIDEO

11:20-11:25 Q&A discussion moderated by David Grelotti, MD

11:25-11:45 Tom Marcotte, PhD - Evaluation of Field Sobriety Tests for Identifying Drivers Under the Influence of Cannabis - LINK to VIDEO

11:45-11:50 Q&A discussion moderated by David Grelotti, MD

11:50-12:00 Closing Remarks from the CMCR Director, Igor Grant, MD

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